The ATM substrate KAP1 controls DNA repair in heterochromatin: regulation by HP1 proteins and serine 473/824 phosphorylation.

@article{White2012TheAS,
  title={The ATM substrate KAP1 controls DNA repair in heterochromatin: regulation by HP1 proteins and serine 473/824 phosphorylation.},
  author={David E. White and Ilona U. Rafalska-Metcalf and Alexey V. Ivanov and Andrea Corsinotti and Hongzhuang Peng and Sheng-Chung Lee and Didier Trono and Susan M. Janicki and F. Rauscher},
  journal={Molecular cancer research : MCR},
  year={2012},
  volume={10 3},
  pages={401-14}
}
The repair of DNA damage in highly compact, transcriptionally silent heterochromatin requires that repair and chromatin packaging machineries be tightly coupled and regulated. KAP1 is a heterochromatin protein and co-repressor that binds to HP1 during gene silencing but is also robustly phosphorylated by Ataxia telangiectasia mutated (ATM) at serine 824 in response to DNA damage. The interplay between HP1-KAP1 binding/ATM phosphorylation during DNA repair is not known. We show that HP1α and… CONTINUE READING

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