The ATM protein is required for sustained activation of NF-κB following DNA damage


Cells lacking an intact ATM gene are hypersensitive to ionizing radiation and show multiple defects in the cell cycle-coupled checkpoints. DNA damage usually triggers cell cycle arrest through, among other things, the activation of p53. Another DNA-damage responsive factor is NF-κB. It is activated by various stress situations, including oxidative stress… (More)
DOI: 10.1038/sj.onc.1202541


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