The ATF6 pathway of the ER stress response contributes to enhanced viability in glioblastoma

@inproceedings{Dadey2016TheAP,
  title={The ATF6 pathway of the ER stress response contributes to enhanced viability in glioblastoma},
  author={David Y. A. Dadey and Vaishali Kapoor and Arpine Khudanyan and Fumihiko Urano and Albert H. Kim and Dinesh Kumar Thotala and Dennis E. Hallahan},
  booktitle={Oncotarget},
  year={2016}
}
Therapeutic resistance is a major barrier to improvement of outcomes for patients with glioblastoma. The endoplasmic reticulum stress response (ERSR) has been identified as a contributor to chemoresistance in glioblastoma; however the contributions of the ERSR to radioresistance have not been characterized. In this study we found that radiation can induce ER stress and downstream signaling associated with the ERSR. Induction of ER stress appears to be linked to changes in ROS balance secondary… CONTINUE READING
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Endoplasmic reticulum stress induces ligand-independent TNFR1-mediated necroptosis in L929 cells

  • S Saveljeva, SL Mc Laughlin, P Vandenabeele, A Samali, MJ. Bertrand
  • Cell death & disease
  • 2015
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