The AT2 receptor--a matter of love and hate.

  title={The AT2 receptor--a matter of love and hate.},
  author={Ulrike Muscha Steckelings and Elena Kaschina and Thomas Unger},
  volume={26 8},
In 1989, the development of specific angiotensin receptor antagonists which distinguish between two angiotensin receptor subtypes (AT1 and AT2) led to a breakthrough in angiotensin research. It turned out, that the AT1 receptor was almost entirely responsible for the "classical" actions of angiotensin II related to the regulation of blood pressure as well as volume and electrolyte balance. However, actions and signal transduction mechanisms coupled to the AT2 receptor remained enigmatic for a… CONTINUE READING

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