The APOE ε4 genotype modulates CSF YKL-40 levels and their structural brain correlates in the continuum of Alzheimer's disease but not those of sTREM2

@inproceedings{Gispert2017TheA,
  title={The APOE ε4 genotype modulates CSF YKL-40 levels and their structural brain correlates in the continuum of Alzheimer's disease but not those of sTREM2},
  author={Juan Domingo Gispert and Gemma C Mont{\'e} and Marc Su{\'a}rez-Calvet and Carles Falc{\'o}n and Alan Tucholka and Santiago Rojas and Lorena Rami and Raquel S{\'a}nchez-Valle and Albert Llad{\'o} and Gernot Kleinberger and Christian Haass and Jos{\'e} Lu{\'i}s Molinuevo},
  booktitle={Alzheimer's & dementia},
  year={2017}
}
INTRODUCTION Among other metabolic functions, the apolipoprotein E (APOE) plays a crucial role in neuroinflammation. We aimed at assessing whether APOE ε4 modulates levels of glial cerebrospinal fluid (CSF) biomarkers and their structural cerebral correlates along the continuum of Alzheimer's disease (AD). METHODS Brain magnetic resonance imaging (MRI) scans were acquired in 110 participants (49 control; 19 preclinical; 27 mild cognitive impairment [MCI] due to AD; 15 mild AD dementia) and… CONTINUE READING

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Current state of Alzheimer’s fluid biomarkers

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