The APOBEC3 cytidine deaminases: an innate defensive network opposing exogenous retroviruses and endogenous retroelements.

@article{Chiu2008TheAC,
  title={The APOBEC3 cytidine deaminases: an innate defensive network opposing exogenous retroviruses and endogenous retroelements.},
  author={Ya-Lin Chiu and Warner C. Greene},
  journal={Annual review of immunology},
  year={2008},
  volume={26},
  pages={317-53}
}
All retroviruses, including HIV-1, display species-specific patterns of infection. The impaired growth of these retroviruses in foreign and sometimes even in their natural hosts often stems from the action of potent host-encoded "viral restriction factors" that form important protective components of the innate immune system. The discovery of APOBEC3G and related cytidine deaminases as one class of host restriction factors and of the action of HIV-1 Vif as a specific APOBEC3G antagonist have… CONTINUE READING
Highly Influential
This paper has highly influenced 15 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

From This Paper

Topics from this paper.
202 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 202 extracted citations

Similar Papers

Loading similar papers…