The APOA5 Trp19 allele is associated with metabolic syndrome via its association with plasma triglycerides

@article{Dallongeville2008TheAT,
  title={The APOA5 Trp19 allele is associated with metabolic syndrome via its association with plasma triglycerides},
  author={Jean Dallongeville and Dominique Cottel and Aline Wagner and Pierre Ducimeti{\`e}re and J B Ruidavets and Dominique Arveiler and Annie Bingham and Jean Ferri{\`e}res and Philippe Amouyel and Aline Meirhaeghe},
  journal={BMC Medical Genetics},
  year={2008},
  volume={9},
  pages={84 - 84}
}
The goal of the present study was to assess the effect of genetic variability at the APOA5/A4/C3/A1 cluster locus on the risk of metabolic syndrome. The APOA5 Ser19Trp, APOA5 -12,238T>C, APOA4 Thr347Ser, APOC3 -482C>T and APOC3 3238C>G (SstI) polymorphisms were analyzed in a representative population sample of 3138 men and women from France, including 932 individuals with metabolic syndrome and 2206 without metabolic syndrome, as defined by the NCEP criteria. Compared with homozygotes for the… CONTINUE READING
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