The APC gene product in normal and tumor cells.

@article{Smith1993TheAG,
  title={The APC gene product in normal and tumor cells.},
  author={Kenneth J. Smith and Kristen A Johnson and Tracy M Bryan and David E Hill and Sanford Markowitz and James K. V. Willson and Christos Paraskeva and G. M. van Petersen and Stanley R. Hamilton and Bert Vogelstein},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1993},
  volume={90 7},
  pages={2846-50}
}
The APC gene has been found to be mutated during the development of sporadic colorectal tumors as well as in the germ line of familial adenomatous polyposis patients. To facilitate the characterization of both normal and mutant APC protein, a series of monoclonal and polyclonal antibodies specific for the APC protein was produced. When lymphoblastoid cell lines derived from seven familial adenomatous polyposis patients with known mutations were analyzed by Western blot, an approximately 300-kDa… CONTINUE READING
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