The AP-2 complex is excluded from the dynamic population of plasma membrane-associated clathrin.

@article{Rappoport2003TheAC,
  title={The AP-2 complex is excluded from the dynamic population of plasma membrane-associated clathrin.},
  author={Joshua Z. Rappoport and Bushra W Taha and Simone Lemeer and Alexandre Benmerah and Sanford M Simon},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 48},
  pages={47357-60}
}
Numerous biologically relevant substrates are selectively internalized via clathrin-mediated endocytosis. At the plasma membrane the AP-2 complex plays a major role in clathrin coat formation, interacting with both cargo and clathrin. Utilizing simultaneous dual-channel total internal reflection fluorescence microscopy we have analyzed components of the AP-2 complex (alpha- and beta 2-adaptin) during clathrin-mediated endocytosis. Although in static images enhanced green fluorescent protein… CONTINUE READING

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