The AP-1 clathrin-adaptor is required for lysosomal enzymes sorting and biogenesis of the contractile vacuole complex in Dictyostelium cells.

@article{Lefkir2003TheAC,
  title={The AP-1 clathrin-adaptor is required for lysosomal enzymes sorting and biogenesis of the contractile vacuole complex in Dictyostelium cells.},
  author={Yaya Lefkir and Beno{\^i}t de Chassey and Annick Dubois and Aleksandra Bogdanovic and Rebecca J Brady and Olivier Destaing and Franz Bruckert and Theresa J. O'Halloran and Pierre Cosson and François Letourneur},
  journal={Molecular biology of the cell},
  year={2003},
  volume={14 5},
  pages={
          1835-51
        }
}
Adaptor protein complexes (AP) are major components of the cytoplasmic coat found on clathrin-coated vesicles. Here, we report the molecular and functional characterization of Dictyostelium clathrin-associated AP-1 complex, which in mammalian cells, participates mainly in budding of clathrin-coated vesicles from the trans-Golgi network (TGN). The gamma-adaptin AP-1 subunit was cloned and shown to belong to a Golgi-localized 300-kDa protein complex. Time-lapse analysis of cells expressing gamma… CONTINUE READING

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