The ANKK1 Protein Associated with Addictions has Nuclear and Cytoplasmic Localization and Shows a Differential Response of Ala239Thr to Apomorphine

@article{Garrido2010TheAP,
  title={The ANKK1 Protein Associated with Addictions has Nuclear and Cytoplasmic Localization and Shows a Differential Response of Ala239Thr to Apomorphine},
  author={Elena Dominguez Garrido and Tom{\'a}s Palomo and Guillermo Ponce and In{\'e}s Garc{\'i}a-Consuegra and M. A. Jim{\'e}nez-arriero and J. Hoenicka},
  journal={Neurotoxicity Research},
  year={2010},
  volume={20},
  pages={32-39}
}
The TaqIA single-nucleotide polymorphism (SNP), which is the most widely studied genetic polymorphism in addictions, is located at the gene that encodes the RIP kinase ANKK1 near the gene for dopamine receptor D2. The TaqIA SNP is in strong linkage disequilibrium with the SNP rs7118900, which changes the alanine at position 239 to threonine in the ANKK1 protein (Ala239/A2; Thr239/A1). In silico analysis has predicted that this polymorphic substitution creates an additional phosphorylation site… CONTINUE READING