The ANK3 Bipolar Disorder Gene Regulates Psychiatric-Related Behaviors That Are Modulated by Lithium and Stress

  title={The ANK3 Bipolar Disorder Gene Regulates Psychiatric-Related Behaviors That Are Modulated by Lithium and Stress},
  author={M. Leussis and Erin Berry-Scott and Mai Saito and Hueihan Jhuang and T. Petryshen},
  journal={Biological Psychiatry},
  • M. Leussis, Erin Berry-Scott, +2 authors T. Petryshen
  • Published 2013
  • Biology, Medicine
  • Biological Psychiatry
  • BACKGROUND Ankyrin 3 (ANK3) has been strongly implicated as a risk gene for bipolar disorder (BD) by recent genome-wide association studies of patient populations. However, the genetic variants of ANK3 contributing to BD risk and their pathological function are unknown. METHODS To gain insight into the potential disease relevance of ANK3, we examined the function of mouse Ank3 in the regulation of psychiatric-related behaviors using genetic, neurobiological, pharmacological, and gene… CONTINUE READING
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