The ANK3 Bipolar Disorder Gene Regulates Psychiatric-Related Behaviors That Are Modulated by Lithium and Stress
@article{Leussis2013TheAB, title={The ANK3 Bipolar Disorder Gene Regulates Psychiatric-Related Behaviors That Are Modulated by Lithium and Stress}, author={Melanie P. Leussis and Erin Berry-Scott and M. Saito and Huei-ting Jhuang and Georgius de Haan and Ozan Alkan and Catherine J. Luce and Jon M. Madison and Pamela Sklar and Thomas Serre and David E. Root and Tracey L. Petryshen}, journal={Biological Psychiatry}, year={2013}, volume={73}, pages={683-690} }
83 Citations
Lithium reverses behavioral and axonal transport-related changes associated with ANK3 bipolar disorder gene disruption
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The ankyrin-3 gene is associated with posttraumatic stress disorder and externalizing comorbidity
- PsychologyPsychoneuroendocrinology
- 2013
AnkG hemizygous mice present cognitive impairment and elevated anxiety/depressive-like traits associated with decreased expression of GABA receptors and postsynaptic density protein
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- 2017
It is possible that the loss of AnkG in the brain disrupts the excitation/inhibition balance of neurotransmitters, hindering the synaptic plasticity of neurons, and consequently leading to abnormal behavioral symptoms, and may constitute a new target for treating neuropsychiatric diseases, especially cognitive dysfunction.
Ankyrin-3 as a molecular marker of early-life stress and vulnerability to psychiatric disorders
- Biology, PsychologyTranslational psychiatry
- 2016
The data suggest that alterations of Ank3 expression and function may contribute to the effects of ELS on the development of psychiatric disorders, and model in humans a gene by early stress interplay on brain phenotypes during cognitive performance.
Disruption of the psychiatric risk gene Ankyrin 3 enhances microtubule dynamics through GSK3/CRMP2 signaling
- Biology, ChemistryTranslational Psychiatry
- 2018
The molecular effects of disrupting brain-specific Ank3 isoforms in mouse and neuronal model systems indicate that ANK3 functions in neuronal microtubule dynamics through GSK3 and its downstream substrate CRMP2.
Genetic disruption of ankyrin-G in adult mouse forebrain causes cortical synapse alteration and behavior reminiscent of bipolar disorder
- Biology, PsychologyProceedings of the National Academy of Sciences
- 2017
A mouse model with conditional disruption of ANK3 gene in neurons in adult forebrain (Ank-G cKO) recapitulates some of the core features of human bipolar disorder and indicates that cortical microcircuitry alterations during adulthood may be involved in pathogenesis.
Association analysis of ANK3 variants with bipolar disorder in the Korean population
- BiologyNordic journal of psychiatry
- 2017
Haplotype analysis results suggest that ANK3 variants rs1938526 and rs10994336 may confer susceptibility for BD in the Korean population, and association analysis revealed a probable genetic difference between Korean and Caucasian populations in the degree of AnK3 involvement in BD pathogenesis.
Roles and mechanisms of ankyrin-G in neuropsychiatric disorders.
- Biology, PsychologyExperimental & molecular medicine
- 2022
Understanding mechanisms leading to potential pathways of pathogenesis in neurodevelopmental and psychiatric disorders, including BD, SZ, and ASD, which are caused by rare pathogenic mutations or changes in the expression levels of ankyrin-G in the brain are elucidated.
Genetic modulation of working memory deficits by ankyrin 3 gene in schizophrenia
- Psychology, MedicineProgress in Neuro-Psychopharmacology and Biological Psychiatry
- 2014
Effects of ANK3 Variation on Gray and White Matter in Bipolar Disorder
- Biology, PsychologyMolecular Psychiatry
- 2017
Findings support effects of rs9804190 on frontotemporal WM in adolescents and adults with BD and suggest a mechanism contributing to WM pathology in BD.
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CONTEXT
Genetic, neuroimaging, and molecular neurobiological evidence support the hypothesis that the disconnectivity syndrome in schizophrenia (SZ) could arise from failures of saltatory conduction…
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