The AMP-regulated kinase family: Enigmatic targets for diabetes therapy

@article{Rutter2009TheAK,
  title={The AMP-regulated kinase family: Enigmatic targets for diabetes therapy},
  author={Guy A Rutter and Isabelle Leclerc},
  journal={Molecular and Cellular Endocrinology},
  year={2009},
  volume={297},
  pages={41-49}
}
AMP-activated protein kinase (AMPK) is a widely conserved Ser/Thr-specific protein kinase, homologous to Saccharomyces cerevisiae Snf1, and involved in nutrient sensing in lower organisms. In 2003, we reviewed the role of this enzyme in glucose homeostasis in mammals [Rutter, G.A., daSilvaXavier, G., Leclerc, I., 2003. Roles of 5'-AMP-activated protein kinase (AMPK) in mammalian glucose homoeostasis. Biochem. J. 375 (Pt 1), 1-16]. In the subsequent 5 years, dramatic strides have taken place in… CONTINUE READING
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References

Publications referenced by this paper.
SHOWING 1-10 OF 112 REFERENCES

Alpha - lipoic acid regulates AMP - activated protein kinase and inhibits insulin secretion from beta cells

  • R. ownley, L. Shapiro
  • Diabetologia
  • 2007

Genome - wide association analysis identifies loci for type 2 diabetes and triglyceride levels

  • F. chuit, A. DeVos, +4 authors M. Prentki
  • Science
  • 2007

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