The AMP-activated protein kinase pathway--new players upstream and downstream.

@article{Hardie2004TheAP,
  title={The AMP-activated protein kinase pathway--new players upstream and downstream.},
  author={David Grahame Hardie},
  journal={Journal of cell science},
  year={2004},
  volume={117 Pt 23},
  pages={5479-87}
}
The AMP-activated protein kinase (AMPK) cascade is a sensor of cellular energy status. Whenever the cellular ATP:ADP ratio falls, owing to a stress that inhibits ATP production or increases ATP consumption, this is amplified by adenylate kinase into a much larger increase in the AMP:ATP ratio. AMP activates the system by binding to two tandem domains on the gamma subunits of AMPK, and this is antagonized by high concentrations of ATP. AMP binding causes activation by a sensitive mechanism… CONTINUE READING
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