The AMP-activated protein kinase activator, 5-aminoimidazole-4-carboxamide-1-b-D-ribonucleoside, regulates lactate production in rat Sertoli cells.

@article{Galardo2007TheAP,
  title={The AMP-activated protein kinase activator, 5-aminoimidazole-4-carboxamide-1-b-D-ribonucleoside, regulates lactate production in rat Sertoli cells.},
  author={Mar{\'i}a Noel Galardo and Mar{\'i}a Fernanda Riera and Eliana Herminia Pellizzari and Selva Beatriz Cigorraga and Silvina Beatriz Meroni},
  journal={Journal of molecular endocrinology},
  year={2007},
  volume={39 4},
  pages={
          279-88
        }
}
The aim of the present study was to investigate whether the AMP-activated protein kinase (AMPK), a key regulator of cellular energy homeostasis, is present in Sertoli cells and whether its activation by 5-aminoimidazole-4-carboxamide-1-b-d-ribonucleoside (AICAR) results in the regulation of cell metabolism to ensure lactate supply for germ cell development. Sertoli cell cultures from 20-day-old rats were used. Western blot analysis for the alpha-subunit of AMPK showed that high levels of AMPK… CONTINUE READING
BETA

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