The AMP-activated protein kinase (AMPK) and cancer: many faces of a metabolic regulator.

  title={The AMP-activated protein kinase (AMPK) and cancer: many faces of a metabolic regulator.},
  author={Brandon Faubert and Emma E. Vincent and M C Poffenberger and Russell G. Jones},
  journal={Cancer letters},
  volume={356 2 Pt A},
The AMP-activated protein kinase (AMPK) is a central regulator of cellular metabolism and energy homeostasis in mammalian tissues. Pertinent to cancer biology is the fact that AMPK is situated in the center of a signaling network involving established tumor suppressors including LKB1, TSC2 and p53. However, recent research suggests that AMPK can exert pro- or anti-tumorigenic roles in cancer depending on context. Loss of AMPK activity has been observed in several tumor types, and can cooperate… CONTINUE READING
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