The AML1-ETO fusion gene and the FLT3 length mutation collaborate in inducing acute leukemia in mice.

@article{Schessl2005TheAF,
  title={The AML1-ETO fusion gene and the FLT3 length mutation collaborate in inducing acute leukemia in mice.},
  author={Christina Schessl and Vijay P S Rawat and Monica Cusan and Aniruddha S. Deshpande and Tobias Kohl and Patricia M. Rosten and Karsten Spiekermann and Richard Keith Humphries and Susanne Schnittger and Wolfgang Kern and Wolfgang Hiddemann and Leticia Quintanilla-Martinez and Stefan K Bohlander and Michaela Feuring-Buske and Christian Buske},
  journal={The Journal of clinical investigation},
  year={2005},
  volume={115 8},
  pages={
          2159-68
        }
}
The molecular characterization of leukemia has demonstrated that genetic alterations in the leukemic clone frequently fall into 2 classes, those affecting transcription factors (e.g., AML1-ETO) and mutations affecting genes involved in signal transduction (e.g., activating mutations of FLT3 and KIT). This finding has favored a model of leukemogenesis in which the collaboration of these 2 classes of genetic alterations is necessary for the malignant transformation of hematopoietic progenitor… CONTINUE READING

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