The ALS/FTLD-related RNA-binding proteins TDP-43 and FUS have common downstream RNA targets in cortical neurons☆

Abstract

TDP-43 and FUS are linked to amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD), and loss of function of either protein contributes to these neurodegenerative conditions. To elucidate the TDP-43- and FUS-regulated pathophysiological RNA metabolism cascades, we assessed the differential gene expression and alternative splicing… (More)
DOI: 10.1016/j.fob.2013.11.001

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Cite this paper

@inproceedings{Honda2013TheAR, title={The ALS/FTLD-related RNA-binding proteins TDP-43 and FUS have common downstream RNA targets in cortical neurons☆}, author={Daiyu Honda and Shinsuke Ishigaki and Yohei Iguchi and Yusuke Fujioka and Tsuyoshi Udagawa and Akio Masuda and Kinji Ohno and Masahisa Katsuno and Gen Sobue}, booktitle={FEBS open bio}, year={2013} }