The ALDH7A1 genetic polymorphisms contribute to development of esophageal squamous cell carcinoma

@article{Wang2014TheAG,
  title={The ALDH7A1 genetic polymorphisms contribute to development of esophageal squamous cell carcinoma},
  author={Haiyong Wang and Lei Tong and Jinyu Wei and Wenting Pan and Lichao Li and Yunxia Ge and Liqing Zhou and Qipeng Yuan and Changchun Zhou and Ming Yang},
  journal={Tumor Biology},
  year={2014},
  volume={35},
  pages={12665-12670}
}
Although the entire etiology of esophageal squamous cell carcinoma (ESCC) is still unclear, alcohol drinking has been identified as a major environmental risk factor. The aldehyde dehydrogenase (ALDH) superfamily members are major enzymes involved in the alcohol-metabolizing pathways. Accumulating evidences demonstrated that ALDH7A1, one of ALDH superfamily members, degrades and detoxifies acetaldehyde generated by alcohol metabolism and have been associated with development and prognosis of… CONTINUE READING
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