The AKT1/NF-kappaB/Notch1/PTEN axis has an important role in chemoresistance of gastric cancer cells

Abstract

The inherent resistance of tumors to DNA damage often limits the efficacy of chemotherapy. The aim of this work is to explore the potential mechanism for development of chemoresistance in gastric cancer. Our data revealed that AKT1 mRNA and protein expression were induced by doxorubicin (a chemotherapeutic agent); the doxorubicin-induced AKT1 expression and… (More)
DOI: 10.1038/cddis.2013.375

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Cite this paper

@inproceedings{Zhou2013TheAA, title={The AKT1/NF-kappaB/Notch1/PTEN axis has an important role in chemoresistance of gastric cancer cells}, author={W. Zhou and X-Q Fu and L-l Zhang and Juhong Zhang and Xiaosong Huang and X S Lu and Lingling Shen and B-N Liu and J. Liu and H-S Luo and J-P Yu and H-G Yu}, booktitle={Cell Death and Disease}, year={2013} }