The AIB1 gene polyglutamine repeat length polymorphism and the risk of breast cancer development

@article{Kleibl2010TheAG,
  title={The AIB1 gene polyglutamine repeat length polymorphism and the risk of breast cancer development},
  author={Zdenek Kleibl and Ondrej Havranek and Stanislav Kormunda and Jan Novotny and Lenka Foretova and Eva Machackova and Jana Soukupova and Marketa Janatova and Spiros Tavandzis and Petr Pohlreich},
  journal={Journal of Cancer Research and Clinical Oncology},
  year={2010},
  volume={137},
  pages={331-338}
}
  • Zdenek Kleibl, Ondrej Havranek, +7 authors Petr Pohlreich
  • Published in Journal of Cancer Research and Clinical Oncology 2010
  • DOI:10.1007/s00432-010-0889-5
PurposeCarriers of BRCA1/2 mutations are at high lifetime risk of breast cancer (BC); however, the BC onset broadly vary in individual patients. Recently, polyglutamine (poly-Q) repeat length polymorphism of the amplified in breast cancer 1 (AIB1) gene was analyzed as a risk factor influencing BC onset in BRCA1/2 mutation carriers with contradictory results.MethodsWe genotyped AIB1 poly-Q repeat in 243 BRCA1/2 mutation carriers, 61 patients with familial BC (negatively tested for the presence… CONTINUE READING

References

Publications referenced by this paper.
SHOWING 1-10 OF 34 REFERENCES

Cancer variation associated with the position of the mutation in the BRCA2 gene

Jan Lubinski, Catherine M. Phelan, +9 authors Steven A. Narod
  • Familial Cancer
  • 2002
VIEW 6 EXCERPTS
HIGHLY INFLUENTIAL

The AIB1 polyglutamine repeat does not modify breast cancer risk in BRCA1 and BRCA2 mutation carriers.

  • Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
  • 2006
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL

Variation in cancer risks, by mutation position, in BRCA2 mutation carriers.

  • American journal of human genetics
  • 2001
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

BRCA1-associated breast and ovarian cancer risks in Poland: no association with commonly studied polymorphisms

Anna Jakubowska, Jacek Gronwald, +11 authors Ute Hamann
  • Breast Cancer Research and Treatment
  • 2009
VIEW 3 EXCERPTS