The AH receptor of the most dioxin-sensitive species, guinea pig, is highly homologous to the human AH receptor.


2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) brings about a wide spectrum of toxic and biochemical changes, most of which are mediated by the AH receptor (AHR). Recent cloning of the AHR from the two most TCDD-resistant laboratory animals, Han/Wistar (Kuopio) rats and hamsters, suggested a critical role for the C-terminal transactivation domain structure in… (More)


  • Blog articles referencing this paper

  • Presentations referencing similar topics