The AH receptor and a novel gene determine acute toxic responses to TCDD: segregation of the resistant alleles to different rat lines.

@article{Tuomisto1999TheAR,
  title={The AH receptor and a novel gene determine acute toxic responses to TCDD: segregation of the resistant alleles to different rat lines.},
  author={Jouni T. Tuomisto and Matti Viluksela and Raimo Pohjanvirta},
  journal={Toxicology and applied pharmacology},
  year={1999},
  volume={155 1},
  pages={
          71-81
        }
}
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD),12 the most toxic congener of dioxins, exhibits wide sensitivity differences between a sensitive Long-Evans (L-E) rat and a resistant Han/Wistar (H/W) rat. The sensitivity is determined probably by two autosomal genes and it is highly end point dependent. The difference is more than 1000-fold for acute toxicity and negligible for CYP1A1 induction. The rat strains were recently shown to have differences in the size of AH receptor (AHR), which mediates… CONTINUE READING
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