The ADRB3 Trp64Arg variant and obesity in African-American breast cancer cases

@article{MckeanCowdin2007TheAT,
  title={The ADRB3 Trp64Arg variant and obesity in African-American breast cancer cases},
  author={Roberta Mckean-Cowdin and Xiujuan Li and Leslie Bernstein and Anne Mctiernan and Rachel Ballard-Barbash and William James Gauderman and Frank D Gilliland},
  journal={International Journal of Obesity},
  year={2007},
  volume={31},
  pages={1110-1118}
}
Objective:To determine if a missense change at codon 64 of ADRB3 (Trp64Arg), a candidate obesity gene, is associated with obesity and levels of subcutaneous or visceral fat in African-American breast cancer cases. Several observational studies have found that women, who are overweight or obese at the time of diagnosis, as well as those who gain weight after diagnosis, are at greater risk for breast cancer recurrence and death than non-overweight women.Design:Prospective cohort of breast cancer… CONTINUE READING