The ADP-ribose-1''-monophosphatase domains of severe acute respiratory syndrome coronavirus and human coronavirus 229E mediate resistance to antiviral interferon responses.

@article{Kuri2011TheAD,
  title={The ADP-ribose-1''-monophosphatase domains of severe acute respiratory syndrome coronavirus and human coronavirus 229E mediate resistance to antiviral interferon responses.},
  author={Thomas Kuri and Klara Kristin Eriksson and Akos Putics and Roland Z{\"u}st and Eric J Snijder and Andrew D. Davidson and Stuart G. Siddell and Volker Thiel and John Ziebuhr and Friedemann Weber},
  journal={The Journal of general virology},
  year={2011},
  volume={92 Pt 8},
  pages={
          1899-905
        }
}
Several plus-strand RNA viruses encode proteins containing macrodomains. These domains possess ADP-ribose-1″-phosphatase (ADRP) activity and/or bind poly(ADP-ribose), poly(A) or poly(G). The relevance of these activities in the viral life cycle has not yet been resolved. Here, we report that genetically engineered mutants of severe acute respiratory syndrome coronavirus (SARS-CoV) and human coronavirus 229E (HCoV-229E) expressing ADRP-deficient macrodomains displayed an increased sensitivity to… CONTINUE READING

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