The ACTH-(4-9) analog, ORG 2766, prevents taxol-induced neuropathy in rats.

@article{Hamers1993TheAA,
  title={The ACTH-(4-9) analog, ORG 2766, prevents taxol-induced neuropathy in rats.},
  author={Frank P. T. Hamers and Christine Pette and Jean P. Neijt and Willem Hendrik Gispen},
  journal={European journal of pharmacology},
  year={1993},
  volume={233 1},
  pages={
          177-8
        }
}
Taxol is a novel and promising oncolytic agent the use of which is hampered by its neurotoxicity. We now describe a taxol-induced neuropathy in rats and its prevention by the adrenocorticotropic hormone-(4-9) (ACTH-(4-9)) analog, ORG 2766. A decrease in sensory nerve conduction velocity was seen in taxol-treated rats, both with daily injections of small amounts (6 mg/kg per week) and with weekly injections of higher amounts (9 mg/kg per week) of taxol. Concomitant administration of ORG 2766… CONTINUE READING

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