The ACT-ONE trial, a multicentre, randomised, double-blind, placebo-controlled, dose-finding study of the anabolic/catabolic transforming agent, MT-102 in subjects with cachexia related to stage III and IV non-small cell lung cancer and colorectal cancer: study design

@inproceedings{Coats2011TheAT,
  title={The ACT-ONE trial, a multicentre, randomised, double-blind, placebo-controlled, dose-finding study of the anabolic/catabolic transforming agent, MT-102 in subjects with cachexia related to stage III and IV non-small cell lung cancer and colorectal cancer: study design},
  author={Andrew J. Stewart Coats and Venkatesan Srinivasan and Jayaraman Surendran and Haritha Chiramana and Shankar Vangipuram and N N Bhatt and Minish Jain and Sandip Shah and Irfhan Ali Hyder Ali and Ho Gwo Fuang and Mohammed Zorah Hassan and John Beadle and Julia Tilson and Bridget-Anne Kirwan and Stefan D. Anker},
  booktitle={Journal of cachexia, sarcopenia and muscle},
  year={2011}
}
AimsCachexia, the wasting disorder associated with a wide range of serious illnesses including cancer, is a major cause of morbidity and mortality. There is currently no widely approved therapeutic agent for treating or preventing cancer-associated cachexia. Colorectal cancer and non-small cell lung cancer have relatively high incidences of cachexia, approximately 28% and 34%, respectively. Neurohormonal overactivity has been implicated in the genesis and progression of cachexia and beta… CONTINUE READING

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