The ACE insertion/deletion polymorphism and risk of cancer, a review and meta-analysis of the literature.

@article{Ruiter2011TheAI,
  title={The ACE insertion/deletion polymorphism and risk of cancer, a review and meta-analysis of the literature.},
  author={Rikje Ruiter and Loes E. Visser and Cornelia M van Duijn and Bruno C. Stricker},
  journal={Current cancer drug targets},
  year={2011},
  volume={11 4},
  pages={421-30}
}
The renin-angiotensin system (RAS) plays an important role in the regulation of the cardiovascular system. In addition to RAS enzymes in plasma, the RAS is present in various local organ systems. Moreover, local expression of the RAS has been shown in various malignant cells. In 1990, an insertion/deletion (I/D) polymorphism in the ACE gene was discovered, accounting for half of the variance of the serum ACE enzyme levels. Serum ACE concentrations were significantly higher in homozygotes with… CONTINUE READING
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