The ACE gene I/D polymorphism is not associated with the blood pressure and cardiovascular benefits of ACE inhibition.

@article{Harrap2003TheAG,
  title={The ACE gene I/D polymorphism is not associated with the blood pressure and cardiovascular benefits of ACE inhibition.},
  author={Stephen Brian Harrap and Christophe Tzourio and François Cambien and Odette Poirier and S{\'e}gol{\'e}ne Raoux and J. W. T. Chalmers and Neil Chapman and Samuel A Colman and Solenn Leguennec and Stephen MacMahon and Bruce Neal and Takayoshi Ohkubo and Mark Woodward},
  journal={Hypertension},
  year={2003},
  volume={42 3},
  pages={297-303}
}
The insertion/deletion (I/D) polymorphism of the angiotensin-converting enzyme (ACE) gene might have consequences for the risks of vascular diseases. We examined the ACE genotype and the effects of a perindopril-based blood pressure-lowering regimen on macrovascular events, dementia, and cognitive decline among hypertensive and nonhypertensive patients with a history of cerebrovascular disease. ACE I/D genotypes were measured in 5688 of 6105 individuals with previous stroke or transient… CONTINUE READING
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Effects of blood pressure lowering with perindopril on dementia and cognitive decline in patients with cerebrovascular disease

  • M Woodward
  • Arch Intern Med
  • 2003

Randomised trial of a perindopril-based blood pressure lowering regimen among 6,105 individuals with previous stroke or transient ischaemic attack

  • PROGRESS Collaborative Group
  • Lancet.
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