The ABCs of solute carriers: physiological, pathological and therapeutic implications of human membrane transport proteins

@article{Hediger2003TheAO,
  title={The ABCs of solute carriers: physiological, pathological and therapeutic implications of human membrane transport proteins},
  author={Matthias A. Hediger and Michael F. Romero and Ji-Bin Peng and Andreas Rolfs and Hitomi Takanaga and Elspeth A. Bruford},
  journal={Pfl{\"u}gers Archiv},
  year={2003},
  volume={447},
  pages={465-468}
}
The Human Genome Organisation (HUGO) Nomenclature Committee Database provides a list of transporter families of the solute carrier (SLC) gene series (see http://www.gene.ucl.ac.uk/nomenclature/). Currently, it includes 43 families and 298 transporter genes. This special issue features mini-reviews on each of these SLC families written by the experts in each field. A WEB site has been established (http://www.pharmaconference.org/slctable.asp) that gives the latest updates for the SLC families… 

Progress in Structural Biology of Solute Carriers

TLDR
The surge of SLC structural studies since 2017 were summarized in several aspects, which include the “very first” structures disclosed in certain SLC families; methodologies used in preparing SLC proteins, determination of structures, and functional assays; vital information obtained from SLC structures; the role of lipids; and some other unanswered questions.

Structural biology of solute carrier (SLC) membrane transport proteins

TLDR
This review provides a systematic analysis of the structure, molecular basis of substrate recognition and mechanism of action in different SLC family members.

The SoLute Carrier (SLC) Family Series in Teleost Fish

TLDR
This chapter gives the latest updates (March 2011) for the SLC families and their members in teleost fish as well as relevant links to GenBank database and literature.

Rational Exploration of Fold Atlas for Human Solute Carrier Proteins

TLDR
This work systematically explored the SLC superfamily to look for more folds and found at least three new folds, and one was experimentally verified in the S LC44 family.

Atypical Solute Carriers Identification , evolutionary conservation , structure and histology of novel membrane-bound transporters

TLDR
The atypical SLCs of MFS type are suggested to be novel SLC transporters, involved in maintaining nutrient homeostasis through substrate transport, in mouse brains and if and how their gene expressions were affected upon changed food intake.

The SLCO (former SLC21) superfamily of transporters.

Solute Carrier Transporters as Potential Targets for the Treatment of Metabolic Disease

TLDR
The evidence for solute carrier (SLC) genes associated with human metabolic diseases are presented and the potential of SLC transporters as therapeutic target structures are discussed.
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