The ABCs of solute carriers: physiological, pathological and therapeutic implications of human membrane transport proteins

  title={The ABCs of solute carriers: physiological, pathological and therapeutic implications of human membrane transport proteins},
  author={Matthias A. Hediger and Michael F. Romero and Ji-Bin Peng and Andreas Rolfs and Hitomi Takanaga and Elspeth A. Bruford},
  journal={Pfl{\"u}gers Archiv},
The Human Genome Organisation (HUGO) Nomenclature Committee Database provides a list of transporter families of the solute carrier (SLC) gene series (see Currently, it includes 43 families and 298 transporter genes. This special issue features mini-reviews on each of these SLC families written by the experts in each field. A WEB site has been established ( that gives the latest updates for the SLC families… 

Progress in Structural Biology of Solute Carriers

The surge of SLC structural studies since 2017 were summarized in several aspects, which include the “very first” structures disclosed in certain SLC families; methodologies used in preparing SLC proteins, determination of structures, and functional assays; vital information obtained from SLC structures; the role of lipids; and some other unanswered questions.

Structural biology of solute carrier (SLC) membrane transport proteins

This review provides a systematic analysis of the structure, molecular basis of substrate recognition and mechanism of action in different SLC family members.

The SoLute Carrier (SLC) Family Series in Teleost Fish

This chapter gives the latest updates (March 2011) for the SLC families and their members in teleost fish as well as relevant links to GenBank database and literature.

Rational Exploration of Fold Atlas for Human Solute Carrier Proteins

This work systematically explored the SLC superfamily to look for more folds and found at least three new folds, and one was experimentally verified in the S LC44 family.

Atypical Solute Carriers Identification , evolutionary conservation , structure and histology of novel membrane-bound transporters

The atypical SLCs of MFS type are suggested to be novel SLC transporters, involved in maintaining nutrient homeostasis through substrate transport, in mouse brains and if and how their gene expressions were affected upon changed food intake.

The SLCO (former SLC21) superfamily of transporters.

Solute Carrier Transporters as Potential Targets for the Treatment of Metabolic Disease

The evidence for solute carrier (SLC) genes associated with human metabolic diseases are presented and the potential of SLC transporters as therapeutic target structures are discussed.



Molecular physiology and pathology of the nucleotide sugar transporter family (SLC35)

Along with LAD II, the possible involvement of nucleotide sugar transporters in disorders of connective tissues and muscles is also discussed.

Organic anion transporting polypeptides of the OATP/SLC21 family: phylogenetic classification as OATP/SLCO superfamily, new nomenclature and molecular/functional properties

All Oatps/OATPs are newly classified within the OATP/SLCO superfamily and subdivided into families, subfamilies and individual genes and gene products according to their phylogenetic relationships and chronology of identification.

Mammalian ABC transporters in health and disease.

This work focuses on three topics: ABC transporters transporting drugs (xenotoxins) and drug conjugates, and a rapidly increasing number of ABC Transporters found to play a role in lipid transport.

The human solute carrier SLC41A1 belongs to a novel eukaryotic subfamily with homology to prokaryotic MgtE Mg2+ transporters.

Copper Transporting P-Type ATPases and Human Disease

Tissue expression studies of the copper ATPases and their copper chaperone ATOX1 indicate that there is not complete overlap in expression, and other chaperones may be important for the transport of copper into ATP7A and ATP7B.

Identification of a Novel System L Amino Acid Transporter Structurally Distinct from Heterodimeric Amino Acid Transporters*

A cDNA that encodes a novel Na+-independent neutral amino acid transporter was isolated from FLC4 human hepatocarcinoma cells by expression cloning and proposed to be a transporter subserving system L2, a new family of organic solute transporters.

An electric lobe suppressor for a yeast choline transport mutation belongs to a new family of transporter-like proteins.

The results establish a new family of genes for transporter-like proteins in eukaryotes and suggest that one of its members, CTL1, is involved in supplying choline to certain cell types, including a specific subset of cholinergic neurons.

ATP synthases: structure, function and evolution of unique energy converters

Recent studies on the molecular biology of the AO/FO/VO domains revealed surprising findings about duplicated and triplicated versions of the proteolipid subunit and shed new light on the evolution of these ion pumps.

Selection and Characterization of the Choline Transport Mutation Suppressor from Torpedo Electric Lobe, CTL1

Northern analysis of Torpedo mRNA indicates that CTL1 is expressed at high levels in the spinal cord and brain, and it is proposed that C TL1 plays a role in providing choline for membrane synthesis in the nervous system.

Cloning and Characterization of MgtE , a Putative New Class of Mg 2 1 Transporter from Bacillus firmus OF 4

The MM281 strain of Salmonella typhimurium which possesses mutations in each its three known Mg transport systems and requires 100 mM Mg for growth was used to screen a genomic library from the