The ABCs of solute carriers: physiological, pathological and therapeutic implications of human membrane transport proteins

@article{Hediger2003TheAO,
  title={The ABCs of solute carriers: physiological, pathological and therapeutic implications of human membrane transport proteins},
  author={Matthias A. Hediger and Michael F. Romero and Ji-Bin Peng and Andreas Rolfs and Hitomi Takanaga and Elspeth A. Bruford},
  journal={Pfl{\"u}gers Archiv},
  year={2003},
  volume={447},
  pages={465-468}
}
The Human Genome Organisation (HUGO) Nomenclature Committee Database provides a list of transporter families of the solute carrier (SLC) gene series (see http://www.gene.ucl.ac.uk/nomenclature/). Currently, it includes 43 families and 298 transporter genes. This special issue features mini-reviews on each of these SLC families written by the experts in each field. A WEB site has been established (http://www.pharmaconference.org/slctable.asp) that gives the latest updates for the SLC families… Expand
The ABCs of membrane transporters in health and disease (SLC series): Introduction
TLDR
The existing online resource for solute carriers, the Bioparadigms SLC Tables, has been updated and significantly extended with additional information and cross-links to other relevant databases, and the nomenclature used in this database has been validated and approved by the HGNC. Expand
Progress in Structural Biology of Solute Carriers
The solute carrier (SLC) family is the second largest family of membrane proteins in the human genome which transports a broad spectrum of substrates such as neurotransmitters, amino acids, lipids,Expand
Structural biology of solute carrier (SLC) membrane transport proteins
TLDR
This review provides a systematic analysis of the structure, molecular basis of substrate recognition and mechanism of action in different SLC family members. Expand
The solute carrier (SLC) complement of the human genome: Phylogenetic classification reveals four major families
TLDR
This study represents the first overall genomic roadmap of the SLCs providing large sequence sets and clarifies the phylogenetic relationships among the families of the second largest group of membrane proteins. Expand
The SoLute Carrier (SLC) Family Series in Teleost Fish
TLDR
This chapter gives the latest updates (March 2011) for the SLC families and their members in teleost fish as well as relevant links to GenBank database and literature. Expand
Rational Exploration of Fold Atlas for Human Solute Carrier Proteins
  • Tengyu Xie, X. Chi, Bangdong Huang, Fangfei Ye, Qiang Zhou, Jing Huang
  • Biology
  • 2021
TLDR
This work systematically explored the SLC superfamily to find more folds and indicates that there are at least three new folds in the solute transporter superfamily among which the S LC44 family is experimentally verified to adopt a new fold. Expand
Atypical Solute Carriers Identification , evolutionary conservation , structure and histology of novel membrane-bound transporters
Perland, E. 2017. Atypical Solute Carriers. Identification, evolutionary conservation, structure and histology of novel membrane-bound transporters. Digital Comprehensive Summaries of UppsalaExpand
The SLCO (former SLC21) superfamily of transporters.
TLDR
This review tries to summarize what is currently known about OATPs with respect to endogenous substrates, tissue distribution, transport mechanisms, regulation of expression, structure-function relationship and mutations and polymorphisms. Expand
The Biology and Function of Transporters
TLDR
Drug transporters are key players in drug–drug interactions, where they are as important as the drug metabolizing enzymes in the absorption and elimination of drugs. Expand
Insights into solute carriers: physiological functions and implications in disease and pharmacokinetics
TLDR
This review compiles the up-to-date knowledge on the natural occurrence of the principal SLC families in human organs and tissues, in particular, highlighting their biological function and dysfunction in disease. Expand
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