The ABCG2 transporter and its relations with the pharmacokinetics, drug interaction and lipid-lowering effects of statins.

Abstract

IMPORTANCE OF THE FIELD The ABCG2 efflux transporter is expressed in multiple tissues and plays an important role in the disposition of many statins. The functional 421C>A polymorphism in ABCG2 that reduces transporter activity has been found to be associated with increased systemic exposures to certain statins. AREAS COVERED IN THIS REVIEW We review and… (More)
DOI: 10.1517/17425255.2011.538383

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