The ABCD's of β-lactamase nomenclature.

  title={The ABCD's of β-lactamase nomenclature.},
  author={Karen Bush},
  journal={Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy},
  volume={19 4},
β-Lactamases can be named on the basis of molecular characteristics or functional properties. Molecular classes A, B, C, and D define an enzyme according to amino acid sequence and conserved motifs. Functional groups 1, 2, and 3 are used to assign a clinically useful description to a family of enzymes, with subgroups designated according to substrate and inhibitor profiles. In addition, other designations are used to define the functionality of specific subgroups, such as extended-spectrum… CONTINUE READING
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