The ABCA1 transporter functions on the basolateral surface of hepatocytes.

  title={The ABCA1 transporter functions on the basolateral surface of hepatocytes.},
  author={Edward B. Neufeld and Steven J. Demosky and John A. Stonik and Christian A. Combs and Alan T Remaley and Nicolas Duverger and Silvia Santamarina-Fojo and Hollis B Brewer},
  journal={Biochemical and biophysical research communications},
  volume={297 4},
ABCA1 on the cell surface and in endosomes plays an essential role in the cell-mediated lipidation of apoA-I to form nascent HDL. Our previous studies of transgenic mice overexpressing ABCA1 suggested that ABCA1 in the liver plays a major role in regulating plasma HDL levels. The site of function of ABCA1 in the polarized hepatocyte was currently assessed by expression of an adenoviral construct encoding a human ABCA1-GFP fusion protein in the polarized hepatocyte-like WIF-B cell line… CONTINUE READING

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