The AB/BA crossover: past, present and future?

  title={The AB/BA crossover: past, present and future?},
  author={Stephen Senn},
  journal={Statistical methods in medical research},
  volume={3 4},
  • Stephen Senn
  • Published 1994 in Statistical methods in medical research
The AB/BA design is reviewed from a historical perspective. Particular attention is paid to the problem of carry-over and various attempts to deal with it. The two-stage procedure, an approach which was popular for many years, is shown to be unsafe. The analysis of AB/BA designs with baseline data is also considered. It is shown that such baselines do not provide a cure for the problem of carry-over; and it is concluded that any rational analysis of such trials will always be dependent on… CONTINUE READING


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