The AAA protein Msp1 mediates clearance of excess tail-anchored proteins from the peroxisomal membrane

@inproceedings{Weir2017TheAP,
  title={The AAA protein Msp1 mediates clearance of excess tail-anchored proteins from the peroxisomal membrane},
  author={Nicholas R Weir and Roarke A. Kamber and James S. Martenson and Vladimir Denic},
  booktitle={eLife},
  year={2017}
}
Msp1 is a conserved AAA ATPase in budding yeast localized to mitochondria where it prevents accumulation of mistargeted tail-anchored (TA) proteins, including the peroxisomal TA protein Pex15. Msp1 also resides on peroxisomes but it remains unknown how native TA proteins on mitochondria and peroxisomes evade Msp1 surveillance. We used live-cell quantitative cell microscopy tools and drug-inducible gene expression to dissect Msp1 function. We found that a small fraction of peroxisomal Pex15… CONTINUE READING

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