The A736V TMPRSS6 Polymorphism Influences Hepatic Iron Overload in Nonalcoholic Fatty Liver Disease

@inproceedings{Valenti2012TheAT,
  title={The A736V TMPRSS6 Polymorphism Influences Hepatic Iron Overload in Nonalcoholic Fatty Liver Disease},
  author={Luca Valenti and Raffaela Rametta and Paola Dongiovanni and Benedetta Maria Motta and Elena Canavesi and Serena Pelusi and Edoardo Alessandro Pulixi and Anna Ludovica Fracanzani and Silvia Fargion},
  booktitle={PloS one},
  year={2012}
}
BACKGROUND & AIMS Hepatic iron accumulation due to altered trafficking is frequent in patients with nonalcoholic fatty liver disease (NAFLD), and is associated with more severe liver damage and hepatocellular carcinoma. The p.Ala736Val TMPRSS6 variant influences iron metabolism regulating the transcription of the hepatic hormone hepcidin, but its role in the pathogenesis of iron overload disorders is controversial. Aim of this study was to evaluate the whether the TMPRSS6 p.Ala736Val variant… CONTINUE READING