The A2aR adenosine receptor controls cytokine production in iNKT cells.

@article{Nowak2010TheAA,
  title={The A2aR adenosine receptor controls cytokine production in iNKT cells.},
  author={Michael Nowak and Lydia Lynch and Simon C. Yue and Akio Ohta and Michail Sitkovsky and Steven P. Balk and Mark Adrian Exley},
  journal={European journal of immunology},
  year={2010},
  volume={40 3},
  pages={682-7}
}
The purine nucleoside adenosine is an important anti-inflammatory molecule, inhibiting a variety of immune cells by adenosine receptor-mediated mechanisms. Invariant NKT (iNKT) cells recognize glycolipids presented on CD1d molecules and produce vigorous amounts of cytokines upon activation, hence regulating immune reactions. The mechanisms polarizing their cytokine pattern are elusive. Previous studies demonstrated that adenosine can suppress IFN-gamma production by iNKT cells. We describe the… CONTINUE READING