The A2aR adenosine receptor controls cytokine production in iNKT cells.

@article{Nowak2010TheAA,
  title={The A2aR adenosine receptor controls cytokine production in iNKT cells.},
  author={Michael Nowak and L. Lynch and S. Yue and A. Ohta and M. Sitkovsky and S. Balk and M. Exley},
  journal={European journal of immunology},
  year={2010},
  volume={40 3},
  pages={
          682-7
        }
}
  • Michael Nowak, L. Lynch, +4 authors M. Exley
  • Published 2010
  • Biology, Medicine
  • European journal of immunology
  • The purine nucleoside adenosine is an important anti-inflammatory molecule, inhibiting a variety of immune cells by adenosine receptor-mediated mechanisms. Invariant NKT (iNKT) cells recognize glycolipids presented on CD1d molecules and produce vigorous amounts of cytokines upon activation, hence regulating immune reactions. The mechanisms polarizing their cytokine pattern are elusive. Previous studies demonstrated that adenosine can suppress IFN-gamma production by iNKT cells. We describe the… CONTINUE READING
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    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 30 REFERENCES
    A2A adenosine receptor protects tumors from antitumor T cells
    545