The A2a/A2b receptor antagonist ZM-241385 blocks the cardioprotective effect of adenosine agonist pretreatment in in vivo rat myocardium.

@article{Lasley2007TheAR,
  title={The A2a/A2b receptor antagonist ZM-241385 blocks the cardioprotective effect of adenosine agonist pretreatment in in vivo rat myocardium.},
  author={Robert D. Lasley and Gentian Kristo and Byron J. Keith and Robert M. Mentzer},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2007},
  volume={292 1},
  pages={H426-31}
}
There is increasing evidence for interactions among adenosine receptor subtypes in the brain and heart. The purpose of this study was to determine whether the adenosine A(2a) receptor modulates the infarct size-reducing effect of preischemic administration of adenosine receptor agonists in intact rat myocardium. Adult male rats were submitted to in vivo regional myocardial ischemia (25 min) and 2 h reperfusion. Vehicle-treated rats were compared with rats pretreated with the A(1) agonist 2… CONTINUE READING

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