The A2 adenosine receptor: guanine nucleotide modulation of agonist binding is enhanced by proteolysis.

@article{Nanoff1991TheAA,
  title={The A2 adenosine receptor: guanine nucleotide modulation of agonist binding is enhanced by proteolysis.},
  author={Christian Nanoff and Kenneth A. Jacobson and Gary L. Stiles},
  journal={Molecular pharmacology},
  year={1991},
  volume={39 2},
  pages={130-5}
}
Agonist binding to the A2 adenosine receptor (A2AR) and its regulation by guanine nucleotides was studied using the newly developed radioligand 125I-2-[4-(2-[2-[(4-aminophenyl)methylcarbonylamino] ethylaminnocarbonyl]ethyl)phenyl]ethylamino-5'-N- ethylcarboxamidoadenosine (125I-PAPA-APEC) and its photoaffinity analog 125I-azido-PAPA-APEC. A single protein of Mr 45,000, displaying the appropriate A2AR pharmacology, is labeled in membranes from bovine striatum, PC12 cells, and frog erythrocytes… CONTINUE READING

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