The A-Current Modulates Learning via NMDA Receptors Containing the NR2B Subunit

@inproceedings{FontnLozano2011TheAM,
  title={The A-Current Modulates Learning via NMDA Receptors Containing the NR2B Subunit},
  author={{\'A}ngela Font{\'a}n-Lozano and Irene Su{\'a}rez-Pereira and David Gonz{\'a}lez-Forero and {\'A}ngel Manuel Carri{\'o}n},
  booktitle={PloS one},
  year={2011}
}
Synaptic plasticity involves short- and long-term events, although the molecular mechanisms that underlie these processes are not fully understood. The transient A-type K(+) current (I(A)) controls the excitability of the dendrites from CA1 pyramidal neurons by regulating the back-propagation of action potentials and shaping synaptic input. Here, we have studied how decreases in I(A) affect cognitive processes and synaptic plasticity. Using wild-type mice treated with 4-AP, an I(A) inhibitor… CONTINUE READING