The A -844G polymorphism in the PAI-1 gene is associated with a higher risk of venous thrombosis in factor V Leiden carriers.

@article{Morange2000TheA,
  title={The A -844G polymorphism in the PAI-1 gene is associated with a higher risk of venous thrombosis in factor V Leiden carriers.},
  author={Pierre Emmanuel Morange and Mireille Henry and David A Tr{\'e}gou{\"e}t and B Granel and Marie Françoise Aillaud and M. C. Alessi and Ir{\'e}ne Juhan-Vague},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2000},
  volume={20 5},
  pages={1387-91}
}
Identification of combined genetic factors in factor V Leiden carriers is important for a more accurate risk assessment for venous thrombosis (VT). Among these individuals, we evaluated the role of polymorphisms of the plasminogen activator inhibitor-1 (PAI-1) gene in the thrombophilic phenotype. A total of 382 factor V Leiden carriers were included in the study. This population was divided into 3 groups. Group 1 (n=168) included individuals with a personal history of VT; group 2 (n=140… CONTINUE READING
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