The A‐ and B‐type cyclin associated cdc2 kinases in Xenopus turn on and off at different times in the cell cycle.

@article{Minshull1990TheAA,
  title={The A‐ and B‐type cyclin associated cdc2 kinases in Xenopus turn on and off at different times in the cell cycle.},
  author={Jeremy Minshull and Roy M. Golsteyn and Caroline S. Hill and Timothy Hunt},
  journal={The EMBO Journal},
  year={1990},
  volume={9}
}
Cyclins play a key role in the induction of mitosis. In this paper we report the isolation of a cyclin A cDNA clone from Xenopus eggs. Its cognate mRNA encodes a protein that shows characteristic accumulation and destruction during mitotic cell cycles. The cyclin A polypeptide is associated with a protein that cross‐reacts with an antibody against the conserved ‘PSTAIR’ epitope of p34cdc2, and the cyclin A‐cdc2 complex exhibits protein kinase activity that oscillates with the cell cycle. This… Expand
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Cyclin A potentiates maturation-promoting factor activation in the early Xenopus embryo via inhibition of the tyrosine kinase that phosphorylates cdc2
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When reading has become a habit, you will not make it as disturbing activities or as boring activity, and you can gain many benefits and importances of reading. Expand
Note added in proof The sequence reported here has been submitted to the EMBL database with the accession number X53745, and the title X.laevis cyclin A cDNA