The Aβ Peptides-Activated Calcium-Sensing Receptor Stimulates the Production and Secretion of Vascular Endothelial Growth Factor-A by Normoxic Adult Human Cortical Astrocytes

@article{Pr2014TheAP,
  title={The Aβ Peptides-Activated Calcium-Sensing Receptor Stimulates the Production and Secretion of Vascular Endothelial Growth Factor-A by Normoxic Adult Human Cortical Astrocytes},
  author={Ilaria Dal Pr{\`a} and Ubaldo Armato and Franco Chioffi and Raffaella Pacchiana and James F. Whitfield and B. S. Sheshadri Chakravarthy and Li Gui and A. Chiarini},
  journal={NeuroMolecular Medicine},
  year={2014},
  volume={16},
  pages={645-657}
}
The excess vascular endothelial growth factor (VEGF) produced in the Alzheimer’s disease (AD) brain can harm neurons, blood vessels, and other components of the neurovascular units (NVUs). But could astrocytes partaking in networks of astrocyte-neuron teams and connected to blood vessels of NVUs contribute to VEGF production? We have shown with cultured cerebral cortical normal (i.e., untransformed) adult human astrocytes (NAHAs) that exogenous amyloid-β peptides (Aβs) stimulate the astrocytes… CONTINUE READING
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