The 9-phenylxanthen-9-yl protecting group

  title={The 9-phenylxanthen-9-yl protecting group},
  author={J. Chattopadhyaya and C. Reese},
  journal={Journal of The Chemical Society, Chemical Communications},
9-Chloro-9-phenylxanthene (4b) reacts with the 5′-hydroxy groups of 2′-deoxyribonucleosides (2)(and their N-acyl derivatives) to give crystalline 9-phenylxanthen-9-yl (pixyl) derivatives (5) in satisfactory to good yields; the pixyl group may be removed by acidic hydrolysis under very mild conditions. 
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Scalable synthesis of substituted 2,7-dimethyl-9-phenylxanthen-9-ol (DMPx-OH): useful for the preparation of crystalline 5′-O-DMPx-protected nucleosides
Abstract A convenient single-step synthesis of several 2,7-dimethyl-9-phenylxanthen-9-ol (DMPx-OH) analogs has been accomplished using a Friedel–Crafts reaction. Treatment of various DMPx-OH withExpand
Protection of 5′‐Hydroxy Functions of Nucleosides
  • H. Seliger
  • Medicine, Chemistry
  • Current protocols in nucleic acid chemistry
  • 2001
A wide variety of acid‐labile and base-labile protecting groups, as well as enzymatic methods for 5‐protection and deprotection are discussed. Expand
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