The 9-A solution: how mRNA pseudoknots promote efficient programmed -1 ribosomal frameshifting.

@article{Plant2003The9S,
  title={The 9-A solution: how mRNA pseudoknots promote efficient programmed -1 ribosomal frameshifting.},
  author={Ewan P Plant and Kristi L Muldoon Jacobs and Jason W Harger and Arturas Meskauskas and Jonathan L Jacobs and Jennifer L. Baxter and Alexey N. Petrov and Jonathan D. Dinman},
  journal={RNA},
  year={2003},
  volume={9 2},
  pages={
          168-74
        }
}
There is something special about mRNA pseudoknots that allows them to elicit efficient levels of programmed -1 ribosomal frameshifting. Here, we present a synthesis of recent crystallographic, molecular, biochemical, and genetic studies to explain this property. Movement of 9 A by the anticodon loop of the aminoacyl-tRNA at the accommodation step normally pulls the downstream mRNA a similar distance along with it. We suggest that the downstream mRNA pseudoknot provides resistance to this… CONTINUE READING

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