The 8818G allele of the agouti signaling protein (ASIP) gene is ancestral and is associated with darker skin color in African Americans

@article{Bonilla2004The8A,
  title={The 8818G allele of the agouti signaling protein (ASIP) gene is ancestral and is associated with darker skin color in African Americans},
  author={C. Bonilla and Lesley-Anne Boxill and S. M. A. Donald and Tyisha Williams and N. Sylvester and E. Parra and S. Dios and Heather L. Norton and M. Shriver and R. Kittles},
  journal={Human Genetics},
  year={2004},
  volume={116},
  pages={402-406}
}
Skin color, a predictor of social interactions and risk factor for several types of cancer, is due to two contrasting forms of melanin, the darker eumelanin and lighter phaeomelanin. The lighter pigment phaeomelanin is the product of the antagonistic function of the agouti signaling protein (ASIP) on the α-melanocyte stimulating hormone receptor (MC1R). Studies have shown that a single-nucleotide polymorphism (SNP) in the 3′UTR of the ASIP gene is associated with dark hair and eyes; however… Expand
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References

SHOWING 1-10 OF 22 REFERENCES
A polymorphism in the agouti signaling protein gene is associated with human pigmentation.
Agouti protein is an antagonist of the melanocyte-stimulating-hormone receptor
Structure and function of ASP, the human homolog of the mouse agouti gene.
Agouti: from mouse to man, from skin to fat.
Agouti signal protein regulation in human melanoma cells.
Genetics of hair and skin color.
  • J. Rees
  • Biology, Medicine
  • Annual review of genetics
  • 2003
Skin pigmentation, biogeographical ancestry and admixture mapping
CYP3A4-V and prostate cancer in African Americans: causal or confounding association because of population stratification?
...
1
2
3
...