The 8818G allele of the agouti signaling protein (ASIP) gene is ancestral and is associated with darker skin color in African Americans

@article{Bonilla2004The8A,
  title={The 8818G allele of the agouti signaling protein (ASIP) gene is ancestral and is associated with darker skin color in African Americans},
  author={Carolina Bonilla and Lesley-Anne Boxill and Stacey Ann Mc Donald and Tyisha Williams and N. Sylvester and Esteban Juan Parra and Sonia Dios and Heather L. Norton and Mark David Shriver and Rick A. Kittles},
  journal={Human Genetics},
  year={2004},
  volume={116},
  pages={402-406}
}
Skin color, a predictor of social interactions and risk factor for several types of cancer, is due to two contrasting forms of melanin, the darker eumelanin and lighter phaeomelanin. The lighter pigment phaeomelanin is the product of the antagonistic function of the agouti signaling protein (ASIP) on the α-melanocyte stimulating hormone receptor (MC1R). Studies have shown that a single-nucleotide polymorphism (SNP) in the 3′UTR of the ASIP gene is associated with dark hair and eyes; however… 
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