The -786C/T single-nucleotide polymorphism in the promoter of the gene for endothelial nitric oxide synthase: insensitivity to physiologic stimuli as a risk factor for rheumatoid arthritis.

@article{Melchers2006TheS,
  title={The -786C/T single-nucleotide polymorphism in the promoter of the gene for endothelial nitric oxide synthase: insensitivity to physiologic stimuli as a risk factor for rheumatoid arthritis.},
  author={Inga Melchers and Sabine Blaschke and Markus Hecker and Marco Cattaruzza},
  journal={Arthritis and rheumatism},
  year={2006},
  volume={54 10},
  pages={3144-51}
}
OBJECTIVE Shear stress is the main physiologic stimulus for the expression of NOS3, the gene for human endothelial nitric oxide synthase. Interestingly, a promoter variant of the NOS3 gene, the -786C variant, is insensitive to shear stress, and individuals homozygous for this single-nucleotide polymorphism (SNP) have an increased risk of developing coronary… CONTINUE READING