The 70 kDa S6 Kinase Complexes with and Is Activated by the Rho Family G Proteins Cdc42 and Rac1

@article{Chou1996The7K,
  title={The 70 kDa S6 Kinase Complexes with and Is Activated by the Rho Family G Proteins Cdc42 and Rac1},
  author={Margaret M. Chou and John Blenis},
  journal={Cell},
  year={1996},
  volume={85},
  pages={573-583}
}
The 70 kDa ribosomol S6 kinase (pp70S6k) plays an important role in the progression of cells through G1 phase of the cell cycle. However, little is known of the signaling molecules that mediate its activation. We demonstrate that Rho family G proteins regulate pp70S6k activity in vivo. Activated alleles of Cdc42 and Rac1, but not RhoA, stimulate pp70S6k activity in multiple cell types. Activation requires an intact effector domain and isoprenylation of Cdc42 and Rac1. Coexpression of Dbl, an… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 93 extracted citations

p70 S6 kinase and actin dynamics

Spermatogenesis • 2012
View 4 Excerpts
Highly Influenced

PLD1 Regulates mTOR Signaling and Mediates Cdc42 Activation of S6K1

Current Biology • 2003
View 7 Excerpts
Highly Influenced

Dynamic visualization of expressed gene networks.

Journal of cellular physiology • 2003
View 12 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 46 references

374 , 457 – 460 . by inducing dephosphorylation of the same subset of sites

J. Raingeaud, S. Gupta, +4 authors R. J. Davis
J . Biol . Chem • 1995
View 2 Excerpts

Cdc 42 and PAKmediated signaling leads to Jun kinase and p 38 Kinase Assays mitogen - activated protein kinase activation

R. A. Cerione
J . Biol . Chem . • 1995

Control of p 70 S 6 kinase by kinase activity catalyzed by a common domain on the dbl oncogene product

S. L. Schreiber
J . Biol . Chem Nature • 1995

Parallel signal processing among mammalian MAPKs.

Trends in biochemical sciences • 1995
View 1 Excerpt

Phosphatidylinositol 3-kinase signals activation of p70 S6 kinase in situ through site-specific p70 phosphorylation.

Proceedings of the National Academy of Sciences of the United States of America • 1995
View 2 Excerpts

Similar Papers

Loading similar papers…