The 64-kDa protein that associates with the platelet-derived growth factor receptor beta subunit via Tyr-1009 is the SH2-containing phosphotyrosine phosphatase Syp.

@article{Kazlauskas1993The6P,
  title={The 64-kDa protein that associates with the platelet-derived growth factor receptor beta subunit via Tyr-1009 is the SH2-containing phosphotyrosine phosphatase Syp.},
  author={Andrius Kazlauskas and Gen Sheng Feng and Tony J. Pawson and Mindaugas Valius},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1993},
  volume={90 15},
  pages={6939-43}
}
Ligand-stimulated autophosphorylation of the platelet-derived growth factor receptor (PDGFR) beta subunit creates a number of binding sites for SH2-containing proteins. One of the PDGFR-associated proteins is a 64-kDa protein of unknown identity and function. We present data indicating that the 64-kDa protein that associates with the activated PDGFR is Syp… CONTINUE READING