The 60-kDa heat shock protein modulates allograft rejection.

  title={The 60-kDa heat shock protein modulates allograft rejection.},
  author={Ohad S. Birk and Serap Gur and Dana Elias and Raanan Margalit and Felix Mor and Pnina Carmi and J Bockov{\'a} and Daniel M. Altmann and Irun R. Cohen},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={96 9},
Allograft rejection is a process of immune reactivity triggered by foreign transplantation antigens. We now demonstrate that the 60-kDa heat shock protein (hsp60), a molecule that is identical in the donor and the recipient, can regulate allograft immunity. In wild-type mice, hsp60 expression was greatly enhanced in allografts being rejected. By using MHC class II (Ealpha) promoter hsp60 transgenic mice either as donors of skin with enhanced expression of hsp60, or as allograft recipients with… CONTINUE READING


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